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Intrauterine Insemination (IUI) 

Intrauterine insemination is a procedure in which sperm are washed and injected in to the uterus using a soft plastic catheter.  IUI is frequently confused with IVF because they sound so similar, but the two procedures are very different.

The insemination procedures is done as close to the time of ovulation as possible. It is usually done with partner/husband sperm, but may also be done using donor sperm (also known as TDI). Usually IUI is done in conjunction with stimulation using oral or injectable fertility drugs, but occasionally may be done without the use of medication. Intrauterine insemination is usually painless but may involve discomfort and bleeding, and rarely infection. The IUI procedure itself does not increase the risk of multiple pregnancies but the fertility drugs used with the cycle may.

IUI Instructions for Princeton IVF Patients

  • Your insurance may require precertification and/or referrals. If so please arrange this as far in advance as possible. Samantha can help you with process
  • If you are on Femara or Clomid and being monitored with ultrasound, please schedule an ultrasound and bloodwork around day 12 or 13 during our morning hours. If you are on injectable medications, you would have already been seen multiple times for ultrasound.
  • When the eggs reach a mature size, you will be given (or take at home), and injection of ovidrel to force ovulation.  IUI will be set up 24-36 hrs after the injection. We do not perform IUI on sundays or major holidays.
  • For safety reasons, inseminations are carefully timed You will be instructed by us what time to produce the specimen.  Your husband may collect the specimen at home by masturbation into the sterile cup that has been provided to you or produce the sample in our collection room.  
  • We now require a signed confirmation and a copy of the photo ID from your husband/ partner.  
  • If you chose to produce at home. please keep the cup warm by keeping it close to the body.  
  • The specimen will be brought back to the lab and washed to separate the sperm from the rest of the semen.  We will also analyze the sperm count and motility on his specimen.  The washing process takes an average of 30-40 minutes.  For safety reasons, we will only process several specimens at a time.
  • The insemination itself only takes several minutes, and you will remain on the table for 15 minutes after the procedure.
  • There are no restrictions on you after you leave.
  • Any discomfort from the procedure should improve quickly. If the pain worsens later in the day, it could be a sign of infection and you should notify the doctor ASAP.
  • If you are on Femara or Clomid, please come in for a progesterone blood test in 1 week after the IUI.
  • If you are on injectables, set up an ultrasound with the doctor in 1 week.