genetic

Editing embryos- fiction, science fiction or both?

Designer babies and gene editing: fiction, science fiction or both: Princeton IVF blog
Researchers in Oregon 

A recent report from Oregon describes how researchers edited the genes in a human embryo.

To many of us, myself included, it sounds a bit scary.

An article in the NY times argues that it is huge leap from gene editing to designer babies, since most human traits require the interaction between a number of genes and the environment

There are thousands of what are called single gene mutation disorders that this gene editing technology may be able fix. Examples of this include Cystic Fibrosis, Tay Sachs disease and Sickle Cell Anemia. These types of diseases are due to a single gene mutation which could potentially be repaired using this technology. Many of these disorders can currently be screened for and diagnosed (if anticipated) during the IVF process using Preimplantion Genetic  Diagnosis (PGD)

Picking out your child's height, or athletic or intellectual abilities are another story. Height alone is likely to controlled by tens of thousands of genes, of which less than a thousand have been identified. Even if all of the genetics could be worked out, the task of editing those genes would be enormous.

So, for now at least, designer babies are the stuff of science fiction.

UK Authorities gives three parent IVF the green light

Several months back, we reported in our blog that the authorities that regulate IVF and other fertility procedures in the UK were considering allowing IVF with mitochondrial transfer to move forward. Mitochondrial transfer is more popularly known as "three parent IVF," because it involves three genetic parents: the woman who provides her chromosomes, the husband who provides his chromosomes and the donor who provides the mitochondria which contain their own DNA.  The HFEA in the UK has now given the green light for tightly regulated research to proceed on mitochondrial transfer. So, now it is likely that fertility researchers in Britain will move forward and learn whether this technique can help couples with mitochondrial diseases.

Genetically testing embryos can improve the chances for pregnancy and lower the risk of multiples

PGD embryos  biopsy

This article which appeared recently in our local paper The Trenton Times (and originaly in the Star Ledger) profiled a laboratory we work with at Princeton IVF called Reprogenetics. The test they discussed called Array cGH involves removing some cells from embryos created during IVF and testing them to compare the amount of genetic material they contain from each of the chromosomes. It enables us to diagnose disorders such as Down Syndrome and Turner Syndrome, avoid putting back most abnormal embryos and select embryos for gender. In comparison to earlier methods it is a more comprehensive chromosome screening technique. Click here to read the article.